NBA DFS, 2025: Top FanDuel, DraftKings picks, lineups, advice for Wednesday, October 22 from a daily Fantasy pro
After a limited NBA DFS player pool with just two games on Tuesday’s Opening Night, 24 teams will take the court on Wednesday. Thus, there’s no shortage of top NBA DFS picks to fill out your daily Fantasy basketball lineups. Stars such as Jalen Brunson, Donovan Mitchell and Giannis Antetokounmpo will take the court, while the likes of Joel Embiid and LaMelo Ball are back after seeing their seasons end early last year due to injuries. Who should you construct your NBA DFS strategy around for Wednesday?
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Before making your NBA DFS picks on sites like DraftKings and FanDuel for Wednesday, Oct. 22, you need to see what Mike McClure has to say.
McClure is a DFS professional with over $2 million in career winnings. He’s also a predictive data engineer at SportsLine who uses a powerful prediction model that simulates every minute of every game 10,000 times, taking factors like matchups, statistical trends and injuries into account.
This allows him to find the best NBA DFS values and create optimal lineups that he shares only at SportsLine. They’re a must-see for any NBA DFS player.
On Tuesday, McClure identified Lakers guard Luka Doncic as one of his top NBA DFS picks on both sites. The result: Doncic had 43 points, 12 rebounds, nine assists, two steals and a block, returning 78.5 points on DraftKings and 76.9 points on FanDuel. Anybody who included him in their lineups could have been well on the way to a profitable day!
For Wednesday, one of McClure’s top NBA DFS picks is Mavericks PF/C Anthony Davis, who is listed at $9,700 on DraftKings and $10,900 on FanDuel. Another part of McClure’s optimal NBA DFS strategy includes rostering Raptors small forward Brandon Ingram ($7,400 on both DraftKings and on FanDuel). Ingram will make his team debut after being traded to Toronto last year but missing the rest of the year due to injury. His season high of 33 points last year came in the season opener as he averaged 22.2 points, 5.6 rebounds and 5.2 assists on the year for New Orleans.
McClure is also targeting a player who could go off for massive numbers on Wednesday! This pick could be the difference between winning your tournaments and cash games or going home with nothing. You absolutely need to see who it is before locking in any lineups.
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