Data Skrive
Having taken three straight, the Kansas City Chiefs (5-3) will face the Buffalo Bills (5-2). The Chiefs are slim favorites (-2.5). The expected point total for the matchup is set at 53.5.
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Chiefs vs. Bills Odds & Betting Lines
Chiefs vs Bills Betting Information updated as of November 2, 2025, 12:33 p.m. ET. Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Chiefs -2.5 -109 -121 53.5 -105 -115
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Chiefs vs. Bills Prediction & Pick
- Pick ATS: Chiefs (-2.5)
- Pick OU: Under (53.5)
- Prediction: Chiefs 25 – Bills 22
How to Watch Kansas City vs. Buffalo
- Game date: Sunday, November 2, 2025
- Time: 4:25 p.m. ET
- Venue: Highmark Stadium
- Location: Orchard Park, New York
- TV: CBS
- Live Boxscore: FOX Sports
Chiefs vs. Bills Recent Matchups
- In their last five head-to-head meetings, Buffalo has defeated Kansas City three times.
- In their last five head-to-head matchups, Buffalo has scored 127 points versus Kansas City, while giving up only 117 points.
Kansas City Betting Info
- In eight Kansas City games this season, it has five wins against the spread.
- The Chiefs have an ATS record of 4-2 when playing as at least 2.5-point favorites this season.
- Kansas City has combined with its opponent to gone over the point total in 37.5% of its contests this year (three times in eight games with a set point total).
- The Chiefs have a 4-2 record in games they played as moneyline favorite (winning 66.7% of those games).
- The Chiefs have a 57.4% chance to win this contest, based on the implied probability of the moneyline.
Chiefs Stats
Stat Average (Total) Rank Pass yards 251.8 (2,014) 5 Rush yards 126.5 (1,012) 9 Points scored 26.8 (214) 4 Pass yards against 177.8 (1,422) 3 Rush yards against 100.0 (800) 11 Points allowed 16.4 (131) 2
Kansas City’s Key Players
Offense
- Patrick Mahomes has 2,099 passing yards (second in the NFL), 17 touchdowns (first in the NFL) and four interceptions this year. He has completed 67% of his passes, averaging 262.4 yards per game and 7.4 per attempt.
- He has tacked on 280 rushing yards (35 per game) and four touchdowns on the ground.
- Travis Kelce has 37 catches for 474 yards and three TDs. In eight games, he is averaging 4.6 catches and 59.3 yards per game.
- Through eight games, Kareem Hunt has amassed 245 yards on the ground, averaging 30.6 yards per game and scoring four touchdowns.
- Hunt has totaled eight catches on nine targets for 57 yards, with one receiving TD.
- Marquise Brown averages four receptions and 39.5 yards per game, and has 316 total receiving yards and 32 catches. He’s gotten 49 total targets, and has caught four touchdown passes.
Defense
- On defense, Nick Bolton has 61 tackles and four TFL in 2025. His tackle total leads the Chiefs.
- George Karlaftis III has 26 tackles, seven TFL, 4.5 sacks, and two passes defended.
- Chamarri Conner has recorded 57 tackles this year.
- Drue Tranquill has two sacks (second on the Chiefs) to go along with his four TFL and 37 tackles this year.
Buffalo Betting Info
- Buffalo has covered the spread three times over seven games with a set total.
- This year, the Bills won ATS in their only game as an underdog of 2.5 points or more.
- Games involving Buffalo have hit the over on four occasions this year.
- The Bills won the only game they’ve played as the underdog this season.
- The implied probability of a win by the Bills based on the moneyline is 46.7%.
Bills Stats
Stat Average (Total) Rank Pass yards 218.4 (1,529) 15 Rush yards 164.4 (1,151) 1 Points scored 29.6 (207) 7 Pass yards against 161.9 (1,133) 2 Rush yards against 150.3 (1,052) 31 Points allowed 20.9 (146) 9
Buffalo’s Key Players
Offense
- Josh Allen has passed for 1,560 yards this year, with 12 touchdowns and four interceptions. He is completing 68% of his attempts while averaging 222.9 yards per game and 7.9 per attempt.
- On the ground, Allen has added five rushing touchdowns and 261 rushing yards (second on the Bills).
- James Cook has scored seven rushing touchdowns, while totaling 753 rushing yards (6 per carry and 107.6 per game).
- Cook has also collected 89 receiving yards (12.7 per game) on 12 catches (1.7 per game). He’s been targeted 14 times and is still looking for his first receiving touchdown.
- Through seven games played this season, Khalil Shakir has 31 catches (4.4 receptions per game on 5.9 targets per game) for 356 yards and three receiving touchdowns.
- Dalton Kincaid has 310 receiving yards and three touchdowns from 21 receptions after getting 27 targets.
Defense
- So far in 2025, Joey Bosa has put up three sacks to go with three TFL and 16 tackles over seven games.
- Cole Bishop has two sacks in addition to his two TFL, 34 tackles, and one interception through seven games.
- Terrel Bernard has intercepted one pass on top of 30 tackles, three TFL, and one pass defended during the 2025 season.
- Greg Rousseau has 18 tackles, three TFL, 2.5 sacks, and two passes defended.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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