The LA Rams (6-2) and San Francisco 49ers (6-3) will wrap up their season series Sunday in Week 10 at Levi’s Stadium in Santa Clara, California. It’s a rematch of their Week 5 meeting, which ended in a 26-23 overtime win by the 49ers as sizable underdogs. Let’s analyze BetMGM Sportsbook’s NFL odds around the Rams vs. 49ers odds and make our expert NFL picks and predictions for the best bets.
The Rams have won 3 consecutive games since their Week 5 loss to the 49ers, all by double-digits. Most recently, they took down the New Orleans Saints, 34-10, in a dominant win at home following their Week 8 bye. They’ve allowed just 20 total points in their last 3 games since giving up 26 to San Francisco in Week 5. Los Angeles ranks second in points allowed per game (15.9) and eighth in scoring (26.1 PPG).
San Francisco has gone 2-2 since beating the Rams, falling to the Tampa Bay Buccaneers and Houston Texans, while also beating the Houston Texans and New York Giants. The 49ers are as injured as any team in the NFL and will be missing DE Nick Bosa, LB Fred Warner and WR Ricky Pearsall once again this week.
Watch the NFL on Fubo!
Rams at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 7:17 p.m. ET.
- Moneyline (ML): Rams -250 (bet $250 to win $100) | 49ers +200 (bet $100 to win $200)
- Against the spread (ATS): Rams -6 (-110) | 49ers +6 (-110)
- Over/Under (O/U): 49.5 (O: -110 | U: -110)
Rams at 49ers key injuries
Rams
- WR Puka Nacua (chest) will play
- WR Jordan Whittington (back) questionable
- CB Darious Williams (shoulder) will play
49ers
- WR Ricky Pearsall (knee) out
- QB Brock Purdy (toe) questionable
Rams at 49ers picks and predictions
Prediction
Rams 30, 49ers 23
The 49ers stunned the Rams as 8.5-point underdogs in Week 5, winning outright on the road in a Thursday night game that went into overtime. The Rams should’ve won that game, but they made too many mistakes that wound up costing them a victory against a shorthanded 49ers team.
This rivalry is too unpredictable to bet a heavy favorite like the Rams are this week at -250 on the moneyline, so we’ll PASS on the ML.
The Rams are 4-1 ATS in their last 5 games against the 49ers, with all 4 wins coming as underdogs. They’re favored for the second straight time, giving San Francisco 6 points on the road. The Rams are healthy and playing some of their best football, winning 3 straight by double digits.
BET RAMS -6 (-110) to win and cover the spread on the road against an inconsistent and somewhat sporadic 49ers team.
The total has gone over the total in 5 of the last 6 meetings between these teams, often resulting in high-scoring affairs where at least 1 team scores 25-plus points. The 49ers offense is healthier than it was in Week 5, but the defense is still a question mark, especially with a weak pass rush.
BET OVER 49.5 (-110) in this NFC West showdown on Sunday.
WIN YOUR FANTASY FOOTBALL LEAGUE! The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Subscribe now!
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
Follow SportsbookWire on Twitter/X and like us on Facebook.
Access more NFL coverage:
TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
