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Jaguars vs. Cardinals, Giants vs. Lions: NFL Week 12 odds, picks

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Post sports gambling editor/producer and digital sports editor Matt Ehalt is back for his second season in the NFL Bettor’s Guide.

Jaguars (-3) over CARDINALS

The Jaguars burned us last week when we backed the Chargers, and that win has us willing to lay the points in this matchup.

Jacksonville can’t afford a slip-up in this game in the tight AFC, while the Cardinals are already onto 2026.

The Jaguars seemingly have found their footing offensively, scoring at least 29 points in each of the last three weeks.

Quarterback Trevor Lawrence isn’t being asked to do too much, with the rushing attack instead taking on the burden.

This week, the Jaguars get a Cardinals defense that has allowed 85 points spanning the last two weeks to the Seahawks and 49ers.

Arizona just isn’t equipped to stop teams, and the offense without Marvin Harrison Jr. isn’t built to keep up in high-scoring affairs.

Jacksonville should win this game by at least a field goal.

The Lions may run wild on the Giants. Getty Images

LIONS (-10.5) over Giants

We hate laying this many points, but there’s the potential for the Lions to put up a 50-burger on this horrendous Giants defense.

The Lions rank seventh in rushing yards per game behind the dynamic tandem of Jahmyr Gibbs and David Montgomery.

The Giants, meanwhile, rank 30th in rushing defense, allowing 149.9 yards per game. They made Packers backup Emanuel Wilson look like Jerome Bettis in his prime last week.

Betting on the NFL?

We expect Jaxson Dart to play and likely perform well, but Detroit is going to be angry after a brutal loss to the Eagles and take it out on the Giants.

(Editor’s note: Pick was submitted for the Nov. 21 edition of The Post, before Dart was ruled out).

Detroit is also 3-0 this year following losses and has won said games by an average of 22.67 points.

An ugly season turns uglier for Big Blue on Sunday in Detroit.

2025 record: 6-15-1
Last week: 1-1; Chargers (L); 49ers (W)

Why Trust New York Post Betting

Matt Ehalt has been picking against the spread since his childhood days when he entered his father’s newspaper pool and even took the top prize on more than one occasion. He specializes in NFL wagers and is quite successful with NCAA brackets.

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