Republic analyzes what went wrong in Cardinals’ loss to Seahawks
Arizona Republic writers Theo Mackie and Greg Moore discuss the Cardinals’ Week 10 loss to the Seattle Seahawks and the team’s long-term future.
The Arizona Cardinals continue their 2025 NFL regular season schedule with an NFL Week 11 game against the San Francisco 49ers today.
The Cardinals are coming off a 44-22 loss against the Seattle Seahawks in their NFL Week 10 game.
The 49ers lost to the Los Angeles Rams in the 10th week of the season, 42-26.
Arizona lost to San Francisco in NFL Week 3 earlier this season, 16-15.
Follow our live updates of the game, which is being played at the Cardinals’ State Farm Stadium in Glendale, Arizona, for the latest score, news, notes and analysis of the Week 11 NFL game on Sunday, Nov. 16.
Watch 49ers at Cardinals with FUBO (free trial)
Bam Knight was untouched as he scored a 6-yard touchdown for the Arizona Cardinals. Chad Ryland’s point after attempt was good.
The nine-play, 72-yard drive was highlighted by a stunning Michael Wilson catch.
Knight, the latest running back to be featured on the injury-riddled Cardinals, has four carries for 20 yards and a touchdown through 15 minutes of play. On the season, he has 48 carries for 157 yards.
Score: 49ers 13, Cardinals 7 (4:18 Q1)
Stepping in as the Cardinals’ No. 1 receiver, Michael Wilson is getting noticed.
Wilson caught a contested 34-yard pass on a play that was flagged for defensive pass interference. The penalty was obviously declined. The play came on third-and-3 from the Arizona 35.
In two offensive series, Wilson has been targeted three times. He has two catches for 39 yards.
Brock Purdy completed a 30-yard pass to George Kittle, who stepped into the end zone as the ball landed in his arms. It was the second touchdown for the 49ers in less than 6 minutes of play.
Purdy was 3-for-4 on the drive for 68 yards. The point after attempt by the 49ers was blocked.
Arizona punted to end its first series. The 49ers started the drive on their own 30 and needed just five plays to score.
Score: 49ers 13, Cardinals 0 (9:51)
Kei’Trel Clark didn’t save a touchdown as much as he delayed it.
After Skyy Moore received the opening kickoff from the Cardinals and returned it 98 yards, Clark made a diving tackle at the Arizona 1.
Christian McCaffrey slipped in for the 1-yard touchdown on the next play. And just 16 seconds into the game, the 49ers led by a touchdown.
Score: 49ers 7, Cardinals 0 (14:44 Q1)
Cardinals vs 49ers schedule: What time is NFL Week 11 game?
The NFL Week 11 game between the Cardinals and 49ers is on Sunday, Nov. 16, at 2:05 p.m. MST, 4:05 p.m. ET.
49ers vs Cardinals TV: What channel is NFL Week 11 game on?
The 49ers vs Cardinals NFL Week 11 game can be seen on FOX.
Cardinals vs 49ers streaming: How do I watch NFL Week 11 game on livestream?
Streaming options for the Cardinals vs 49ers game include FUBO, which offers a free trial, and other streaming services that carry FOX, like Sling.
49ers vs Cardinals announcers: Who is calling the NFL Week 11 game?
Kevin Kugler (play-by-play) and Daryl Johnston (analyst) are scheduled to be the announcers for the Cardinals-49ers Week 11 NFL game.
Cardinals vs 49ers game odds: Who is favored in NFL Week 11?
The 49ers are a 2.5-point favorite over the Cardinals in NFL Week 11 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -150 on the moneyline, while Arizona is +125.
The over/under (point total) is set at 48.5 points.
49ers vs Cardinals picks, predictions: Who will win NFL Week 11 game?
The Arizona Republic’s Jeremy Cluff is predicting a 27-23 win for the 49ers over the Cardinals in the Week 11 NFL game today.
Other sites lean toward San Francisco beating the Arizona in their Cardinals vs 49ers NFL Week 11 picks and NFL Week 11 predictions for Nov. 16.
Pregame reading for Cardinals vs 49ers Week 11 NFL game today
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