Syracuse heads to South Bend on Saturday for a daunting Week 13 matchup, taking on a Notre Dame team that enters as one of the largest favorites on the college football board. The latest odds list the Orange as 35.5-point underdogs, with Dimers’ 10,000-simulation model giving Notre Dame a 99% chance of winning at Notre Dame Stadium. The Fighting Irish are projected to control the game on both sides of the ball, with a predicted final score of 41–6 reflecting just how heavily the numbers lean toward a dominant performance from the home team.
Still, the data points to a few angles that could make this matchup more compelling than the spread suggests. Syracuse and Notre Dame are rated as having an equal 50% chance to cover the massive line, and the total of 50.5 carries a slight lean toward the over at 52%—which aligns with Dimers’ best bet of Over 50.5. With kickoff set for 3:30 p.m. EST in one of college football’s most storied venues, the model expects Notre Dame to dictate the flow, but Syracuse’s ability to find scoring pockets and pressure the total will be a key storyline to watch.
Syracuse vs. Notre Dame betting preview
Utilize the interactive widget below to discover the latest spread, total, and moneyline betting odds and probabilities for the Syracuse-Notre Dame game at Notre Dame Stadium.
This prediction and best bet for Saturday’s college football matchup between Syracuse and Notre Dame is from Dimers.com, a reliable source for sports betting predictions.
Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.
Game details
The key information you need before the Syracuse vs. Notre Dame college football game.
- Teams: Syracuse vs. Notre Dame
- Date: Saturday, November 22, 2025
- Kickoff: 3:30 p.m. EST
- Location: Notre Dame Stadium
- NCAAF rankings: Updated AP Top 25
- College football news: Check the latest updates from the official NCAA football news site
Odds
The latest and best odds for the college football clash between the Syracuse and Notre Dame.
- Spread: Syracuse +35.5 (-105), Notre Dame -35.5 (-108)
- Moneyline: Syracuse +7000, Notre Dame -50000
- Total: Over/Under 50.5 (-110/-105)
The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.
Please note that in New York, you cannot bet on in-state college teams. This applies to both home and road games. That said, you can bet on college teams from schools located outside of the state.
Expert prediction: Syracuse vs. Notre Dame
Using cutting-edge data analysis and machine learning, the experts at Dimers have executed 10,000 simulations of Saturday’s Syracuse vs. Notre Dame matchup.
According to Dimers’ popular predictive analytics model, Notre Dame is more likely to beat Syracuse at Notre Dame Stadium. This prediction is based on the model giving Notre Dame a 99% chance of winning the game.
Furthermore, Dimers predicts that the bookmakers have gotten it right and Syracuse and Notre Dame each have a 50% chance of covering the spread, while the over/under total of 50.5 points has a 52% chance of going over.
As always, these predictions and probabilities are accurate at the time of publication but are subject to change.
Syracuse vs. Notre Dame best bet
Our top pick for the Syracuse vs. Notre Dame game on Saturday is to bet on Over 50.5 points (-110).
This betting advice is based on cutting-edge modeling and valuable betting intelligence, designed to deliver you the best possible plays.
Score prediction for Syracuse vs. Notre Dame
Dimers’ predicted final score for the Syracuse vs. Notre Dame game on Saturday has Notre Dame winning 41-6.
This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.
College football Week 13: Syracuse vs. Notre Dame
Get ready for Saturday’s college football game between Syracuse and Notre Dame at Notre Dame Stadium, which is scheduled to start at 3:30 p.m. EST. We emphasize that all of the college football predictions and college football best bets on this page are derived from 10,000 data-driven simulations of the Syracuse vs. Notre Dame matchup, and they are accurate at the time of publishing. They are intended to help you make better decisions when placing bets at online sportsbooks.
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