Data Skrive
The Kansas City Chiefs (5-5) are favored by 4.5 points against the Indianapolis Colts (8-2) on November 23, 2025, starting at 1 p.m. ET, airing on CBS. The total for this one is set at 50.5 points.
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Chiefs vs. Colts Odds & Betting Lines
Chiefs vs Colts Betting Information updated as of November 23, 2025, 12:33 p.m. ET. Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Chiefs -4.5 -107 -124 50.5 -108 -112
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Chiefs vs. Colts Prediction & Pick
- Pick ATS: Colts (+4.5)
- Pick OU: Under (50.5)
- Prediction: Colts 25 – Chiefs 24
How to Watch Kansas City vs. Indianapolis
- Game date: Sunday, November 23, 2025
- Time: 1 p.m. ET
- Venue: GEHA Field at Arrowhead Stadium
- Location: Kansas City, Missouri
- TV: CBS
- Live Boxscore: FOX Sports
Chiefs vs. Colts Recent Matchups
- Over their last four meetings, Indianapolis has three wins against Kansas City.
- Indianapolis has been outscored by 2 points in its last four tilts versus Kansas City.
Kansas City Betting Info
- Kansas City has played 10 games, posting five wins against the spread.
- The Chiefs have been favored by 4.5 points or more six times this season, and covered the spread in three of those games.
- Kansas City games this year have hit the over on three of 10 set point totals (30%).
- When playing as the moneyline favorite, the Chiefs have won 50% of the time (4-4).
- The Chiefs have a 68.6% chance to win this contest, based on the implied probability of the moneyline.
Chiefs Stats
Stat Average (Total) Rank Pass yards 248.9 (2,489) 5 Rush yards 115.3 (1,153) 16 Points scored 25.4 (254) 11 Pass yards against 196.8 (1,968) 11 Rush yards against 100.0 (1,000) 9 Points allowed 18.1 (181) 4
Kansas City’s Key Players
Offense
- Patrick Mahomes has 2,625 passing yards (fifth in the NFL), 18 touchdowns (seventh in the NFL) and six interceptions this year. He has completed 64.5% of his attempts, averaging 262.5 yards per game and 7.3 per attempt.
- He has tacked on 288 rushing yards (28.8 per game) and four touchdowns on the ground.
- Travis Kelce has caught 50 passes on 66 targets for 631 total yards and four touchdowns. He is averaging five catches and 63.1 yards per game through 10 games.
- Through 10 games, Kareem Hunt has picked up 353 rushing yards, averaging 35.3 yards per game and scoring six touchdowns.
- Hunt also has 10 catches, 66 yards and one TD in the passing game.
- Marquise Brown has 38 receptions for 429 yards and four touchdowns. He’s been targeted 57 times in the air attack, and averages 3.8 receptions and 42.9 yards in 10 games played.
Defense
- On the defensive side for the Chiefs, Nick Bolton has put up 81 tackles and five TFL in 2025.
- Chamarri Conner has 70 tackles, one TFL, and one sack.
- George Karlaftis III has totaled 35 tackles, eight TFL, and five sacks this year.
- This season, Trent McDuffie has 50 tackles, two TFL, one sack, and one interception.
Indianapolis Betting Info
- Indianapolis has covered the spread six times in 10 games with a set total.
- The Colts have been underdogs by 4.5 points or more one time this year and have not covered the spread once.
- Indianapolis games have gone over the total six times this season.
- This season, the Colts have won two out of the three games in which they’ve been the underdog.
- The Colts have a 35.7% chance to win this game based on the implied probability of the moneyline.
Colts Stats
Stat Average (Total) Rank Pass yards 251.6 (2,516) 3 Rush yards 145.3 (1,453) 3 Points scored 32.1 (321) 1 Pass yards against 235.3 (2,353) 25 Rush yards against 92.3 (923) 5 Points allowed 20.6 (206) 9
Indianapolis’ Key Players
Offense
- Jonathan Taylor has rushed for 15 touchdowns this year, and has accumulated 1,139 total rushing yards (113.9 per game and 6 per carry).
- Taylor has also been a piece of the receiving game with 260 yards (26 per game) on 30 receptions (three per game), while being targeted 32 times. He has two receiving touchdowns.
- Through 10 games, Daniel Jones has 2,659 passing yards (fourth-best in the NFL), with 15 touchdowns against seven interceptions and completing 69.9% of his passes.
- Jones also has five rushing touchdowns and 143 rushing yards (second on the Colts).
- Michael Pittman Jr. has totaled 580 receiving yards and six touchdowns (eighth in the NFL) on 54 receptions, while being targeted 70 times this season.
- Tyler Warren has 50 catches for 617 yards and three receiving touchdowns. He averages five yards per game through 10 games and has been targeted 67 times.
Defense
- In 2025, Nick Cross has amassed 69 tackles, four TFL, 2.5 sacks, and one interception through 10 games.
- Zaire Franklin has 60 tackles, three TFL, two sacks, and four passes defended.
- Laiatu Latu has five sacks (first on the Colts) in addition to his six TFL, 26 tackles, and two interceptions.
- Germaine Pratt has put up three TFL and 63 tackles through nine games.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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