Joshua Zirkzee starts for the first time this season for Manchester United as Matheus Cunha misses out after suffering a blow to the head in training.
The incident forced the Brazil international to pull out of switching on the Altrincham Christmas lights on Saturday.
Benjamin Sesko is out with a knee injury, so 18-year-old forward Shea Lacey is named on the bench for the first time.
Leny Yoro replaces Harry Maguire in defence while Lisandro Martinez returns to Ruben Amorim’s squad for the first time since February after major knee surgery.
Manchester United XI: Lammens, Yoro, De Ligt, Shaw, Mazraoui, Casemiro, Fernandes, Dorgu, Amad, Mbeumo, Zirkzee.
Substitutes: Bayindir, Dalot, Martinez, Mount, Malacia, Ugarte, Heaven, Mainoo, Lacey.
Veteran Everton skipper Seamus Coleman returns to David Moyes’ side in the only change to the team that beat Fulham 2-0 a fortnight ago.
Tim Iroegbunam drops to the bench as Everton look for their first away win since August.
Everton XI: Pickford, Garner, Tarkowski, Keane, Mykolenko, Coleman, Gueye, Ndiaye, Dewsbury-Hall, Grealish, Barry.
Substitutes: Travers, King, McNeil, Beto, O’Brien, Dibling, Alcaraz, Aznou, Iroegbunam.
