Matheus Cunha returns after a two-match absence with a head injury, one of three changes to the Manchester United side that beat Crystal Palace on Sunday.
Defender Matthijs de Ligt misses out completely, while Mason Mount and Leny Yoro drop to the bench as Noussair Mazraoui comes in and Ayden Heaven makes his first league start of the season.
United are aiming to end a run of four defeats in their last five against tonight’s opponents
Manchester United XI: Lammens, Mazraoui, Heaven, Shaw, Amad, Casemiro, Bruno Fernandes, Dalot, Mbeumo, Cunha, Zirkzee.
Substitutes: Bayindir, Martinez, Mount, Malacia, Dorgu, Yoro, Ugarte, Mainoo, Lacey.
Playmaker Lucas Paqueta is ruled out for West Ham through suspension following his red card against Liverpool on Sunday.
Czech Republic midfielder Thomas Soucek is recalled, the only change to Nuno Espirito Santo’s starting line-up from that defeat.
West Ham are without a number of experienced players who were substitutes at the weekend, including striker Niclas Fullkrug.
West Ham XI: Areola, Wan-Bissaka, Mavropanos, Todibo, Diouf, Magassa, Potts, Bowen, Soucek, Mateus Fernandes, Wilson.
Substitutes: Hermansen, Walker-Peters, Kilman, Rodriguez, Irving, Earthy, Marshall, Kante, Mayers.
