The Tennessee Titans (2-10) visit the San Francisco 49ers (9-4) Sunday in Week 15. Kickoff from Levi’s Stadium in Santa Clara, California, is scheduled for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Titans vs. 49ers odds and make our expert NFL picks and predictions for the best bets.
The Titans are coming off their second win of the season, snapping a 7-game losing streak. RB Tony Pollard rushed for 161 yards and 2 touchdowns in a 31-29 road win over the Cleveland Browns in Week 14, covering as 3-point underdogs with the Over (33) cashing. The Titans built a 31-17 lead midway through the fourth quarter before Cleveland scored 12 unanswered points. However, the Browns failed on a 2-point attempt with 1:03 remaining, which would have tied the game.
The 49ers are coming off their bye week. They have won their last 3 games and held their last 2 opponents under 10 points. They defeated the Browns 26-8 in Week 13, covering as 5.5-point road favorites with the Under (35.5) cashing.
The 49ers lead the all-time series against the Titans 9-6, but the Titans defeated the Niners 20-17 as 3.5-point home underdogs in their last meeting in December 2021.
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Titans at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 4:23 p.m. ET.
- Moneyline (ML): Titans +650 (bet $100 to win $650) | 49ers -1000 (bet $1,000 to win $100)
- Against the spread (ATS): Titans +12.5 (-110) | 49ers -12.5 (-110)
- Over/Under (O/U): 44.5 (O: -110 | U: -110)
Titans at 49ers key injuries
Titans
- CB Jaylin Armour-Davis (Achilles) out
- OL Lloyd Cushenberry III (foot) questionable
- OL Dan Moore Jr. (neck) questionable
- OL Kevin Zeitler (groin) questionable
49ers
- LB Tatum Bethune (ankle) out
- DE Sam Okuayinonu (ankle) out
Titans at 49ers picks and predictions
Prediction
49ers 31, Titans 13
The Titans’ only wins this season have come against the 3-win Cardinals and the 3-win Browns, and those 2 wins were by a combined 3 points.
The 49ers are rested and have averaged 29.4 points per game over their last 5 games.
Nothing suggests the Titans will upset the 49ers, and the -1000 odds to bet the Niners’ ML don’t make sense given the amount you have to risk to win anything.
PASS.
The 49ers are 8-1 ATS in their wins this season, and two of their last 3 victories have been by at least 18 points.
Six of the Titans’ 10 losses have been by more than 12 points.
BET 49ERS -12.5 (-110).
The 49ers have allowed a combined 17 points in their last 2 games.
The Titans’ last 5 games have alternated between the Over and Under hitting, with last week’s game going Over.
BET UNDER 44.5 (-110).
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