Manchester City make seven changes to the side that beat Crystal Palace on Sunday.
James Trafford starts in goal, with Rico Lewis, Abdukodir Khusanov, Nathan Ake, Oscar Bobb and Savinho coming into the side.
Academy star Divine Mukasa starts up front in place of Erling Haaland.
Gianluigi Donnarumma, Matheus Nunes, Ruben Dias, Josko Gvardiol, Bernardo Silva and Phil Foden all drop to the bench.
Man City XI: Trafford, Lewis, Khusanov, Ake, O’Reilly, Gonzalez, Reijnders, Bobb, Cherki, Savinho, Mukasa.
Subs: Donnarumma, Dias, Haaland, Bernardo, Gvardiol, Nunes, Foden, Gray, Mfuni.
Brentford make six changes following the weekend’s draw at Leeds.
Hakon Valdimarsson starts in goal in place of Caoimhin Kelleher, while Rico Henry, Kristoffer Ajer, Mikkel Damsgaard, Yehor Yarmolyuk and Kevin Schade come into the side.
Brentford XI: Valdimarsson, Henry, Van den Berg, Collins, Ajer, Kayode, Jensen, Yarmoliuk, Damsgaard, Janelt, Schade.
Subs: Kelleher, Hickey, Pinnock, Lewis-Potter, Peart-Harris, Konak, Donovan, Arthur, Nunes.
