NFL DFS, Thanksgiving 2025: Lions-Packers, Cowboys-Chiefs, Ravens-Bengals top FanDuel, DraftKings picks, lineups from a daily Fantasy pro

The 2025 Thanksgiving NFL schedule is among the best ever for Turkey Day and is loaded with high-quality options to utilize in NFL DFS lineups. Packers vs. Lions kicks things off at 1 p.m. ET, followed by Chiefs vs. Cowboys at 4:30 p.m. ET and Bengals vs. Ravens at 8:20 p.m. ET. Your daily Fantasy football strategy could lean towards those familiar with NFL Thanksgiving games like Jared Goff, Jahmyr Gibbs, Dak Prescott and CeeDee Lamb. Or, you could lean towards newcomers to the holiday that are in the Thanksgiving DFS player pool such as Patrick Mahomes, Travis Kelce, Ja’Marr Chase or Joe Burrow, who is expected to return from a toe injury for the Bengals.

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Before making any NFL DFS picks for Thanksgiving Day on sites like DraftKings and FanDuel, you NEED to hear what SportsLine daily Fantasy expert Mike McClure has to say.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up!

One of McClure’s top NFL DFS picks for Thanksgiving is Chiefs tight end Travis Kelce at $5,000 on DraftKings and $6,000 on FanDuel. He’s also building around Bengals running back Chase Brown ($7,200 on FanDuel, $6,500 on DraftKings), who has increased his scrimmage yards in each of the last six games, with 130 yards last week.

McClure is also targeting an overlooked value player who could go off for MASSIVE numbers on Thanksgiving! This pick could be the difference between winning your tournaments and cash games or going home with nothing! You ABSOLUTELY need to see who they are before locking in any lineups.

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