Ruben Amorim makes two changes to the side that won at Liverpool.
Benjamin Sesko replaces Mason Mount, who drops to the bench. Leny Yoro comes in for Harry Maguire, who is not involved.
Amorim said on Friday Maguire had picked up a knock. He is replaced in the squad by Tyrrell Malacia, who is involved for the first time since being placed in the ‘bomb squad’ by Amorim at the start of pre-season training.
Manchester United XI: Lammens, Yoro, De Ligt, Shaw, Diallo, Casemiro, Bruno Fernandes, Dalot, Mbeumo, Cunha, Sesko.
Subs: Bayindir, Mazraoui, Zirkzee, Dorgu, Malacia, Ugarte, Heaven, Mount, Mainoo.
Danny Welbeck returns to his old club in form after scoring four goals in his last three games.
Brighton coach Fabian Hurzeler brings in Maxim De Cuyper for Diego Gomez, the only change from the side that beat Newcastle.
The Seagulls have won on their last three visits to Old Trafford and six out of their last eight games against United.
Brighton XI: Verbruggen, Wieffer, Van Hecke, Dunk, Kadioglu, Baleba, Ayari, Minteh, Rutter, De Cuyper, Welbeck.
Subs: Steele, Tzimas, Watson, Kostoulas, Milner, Boscagli, Gomez, Coppola, Oriola.
