LA Rams at San Francisco 49ers Betting Odds, Picks, and Predictions for Week 10

The Rams and 49ers battle out west in Week 10. Despite a rash of injuries, NFL Betting Expert Eric Timm likes the resiliency of the home side.

Rams at 49ers Betting Odds, Picks, and Predictions for Week 10

Citing mental and physical fatigue, my esteemed editor has given me the week off from covering OUR Chicago Bears. Although the Over was the easiest winning play in last week’s game, the trauma received from the ridiculous ending is real. So, in the equivalent of sending grandpa to Shady Acres, I get to cover a cute little NFC West game. Or, so I thought. Have you seen the way this line has moved? From my rocking chair, with an afghan over my lap, I dive in. 

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Rams at 49ers Betting Odds

• Spread: Rams -5.5 (-109 BetRivers), 49ers +6 (-110 Bet365, BetMGM, Caesars)
• Moneyline: Rams -245 (FanDuel) / 49ers +225 (ESPN Bet)
• Total: Over 49.5 (+100 ESPN Bet), Under 49.5 (-109 Caesars)

The disparity in the line from book to book is very interesting. Rarely does it reach 1.5 points, particularly in the NFL, and I’m not really sure why that is. The Niners’ injury woes are well documented, and you never know if WR Puka Nacua is going to make it through the next 10 minutes, much less an entire game. 

In general, the game opened at 3.5, and has landed in the current range, following the bets and money, both of which are on the side of the Rams. The total hasn’t moved an inch from 49.5 despite over 80 percent of the bets and money being on the Under. 

Check updated NFL odds to find the best prices for your favorite bets all season. 

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Rams at 49ers Betting Picks

This is a fascinating game to me. Blindly, most folks would say the Rams are the better team and the Niners are down. Yet, both teams sport six wins and sit atop the NFC West along with Seattle. The 49ers have found ways to work around all of their injuries, and they have dominated this rivalry. If you can find +6, I’d jump on it. But for this article, I’m recommending the value on the 49ers’ moneyline. They find ways to win, and it is worth the play here. 

Rams at 49ers Best Bet: 49ers ML (+225 ESPN Bet)