Mikel Arteta names Piero Hincapie at centre back in place of the injured Gabriel Magalhaes. Mikel Merino continues upfront in place of Viktor Gyokeres who is also out injured.
There is positive news as Noni Madueke and Gabriel Martinelli are back on the bench after injury.
Arsenal starting XI: Raya, Timber, Saliba, Hincapie, Calafiori, Zubimendi, Rice, Eze, Saka, Trossard, Merino
Subs: Arrizabalaga, White, Mosquera, Martinelli, Norgaard, Madueke, Nwaneri, Lewis-Skelly, Dowman
Thomas Frank reverts to a back three for the match with Arsenal. Kevin Danso comes in at centre back while Mohammed Kudus starts.
Tottenham starting XI: Vicario, Spence, Romero, Danso, Van de Ven, Udogie, Palhinha, Bentancur, Richarlison, Odobert, Kudus
Subs: Kinsky, Tel, Gray, Simons, Bergvall, Johnson, Porro, Sarr, Muani
