Joao Gomes misses out through suspension for the hosts, who are seeking their first win of the season and their first point or goal under new manager Rob Edwards.
Ki-Jana Hoever replaces the Brazilian, while Ladislav Krejci returns in defence in place of Jackson Tchatchoua.
Wolves XI: Johnstone, Mosquera, Agbadou, T Gomes, Krejci, Andre, Hoever, Moller Wolfe, Arias, Strand Larsen, Bellegarde.
Subs: Sa, H Bueno, S Bueno, Hwang, Arokodare, Chirewa, Lopez, Mane, Tchatchoua.
Ruben Amorim makes one change to the side that drew with West Ham on Thursday as Mason Mount replaces Joshua Zirkzee, who drops to the bench.
It means Amorim keeps faith with young defender Ayden Heaven at the centre of his three-man defence and Matheus Cunha is included against his former club.
Kobbie Mainoo remains on the bench alongside fellow United academy product Shea Lacey, who is yet to make his debut.
Manchester United XI: Lammens, Mazraoui, Heaven, Shaw, Amad, Casemiro, Fernandes, Dalot, Mbeumo, Mount, Cunha.
Subs: Bayindir, Martinez, Zirkzee, Malacia, Dorgu, Yoro, Ugarte, Mainoo, Lacey.
