Portland vs. Oregon prediction: Oregon favored to win men’s college basketball matchup [12/17/2025]

Oregon will take on Portland in men’s college basketball action at Matthew Knight Arena on Wednesday, starting at 11:00 PM ET.

Based on the latest simulations, Dimers’ advanced college basketball model predicts Oregon as the most likely winner of the Portland vs. Oregon game.

This article offers an expanded analysis of Wednesday’s matchup, including an expanded look at the predicted score, best bets and picks.

Portland vs. Oregon prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday’s NCAA basketball game between Portland and Oregon 10,000 times as part of our men’s college basketball predictions coverage.

Our famous predictive model currently gives Oregon a 96% chance of defeating Portland. Our predicted final score has Oregon winning 86-65.

According to our model, Oregon (-19.5) has a 53% chance of covering the spread, while the over/under total of 154.5 points has a 54% chance of staying under.

Portland vs. Oregon odds

We have researched the best men’s college basketball odds in America for this game, which are listed here:

Bet Type
Portland
Oregon

Spread
+19.5 (-115)
-19.5 (-105)

Moneyline
+1400
-2400

Total
o154.5 (-105)
u154.5 (-110)

All odds are correct at the time of publication and are subject to change.

Portland vs. Oregon picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: