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Warriors vs. Lakers odds, line: Proven model reveals picks for NBA season-opening matchup

NBA Pacific Division rivals tip off the 2025-26 NBA season when the Golden State Warriors take on the Los Angeles Lakers on Tuesday night. Los Angeles forward LeBron James (sciatica) is out and is not expected to make his season debut until mid-November. The Warriors (48-34), who finished third in the division a year ago, were 29-23 within the Western Conference last season. The Lakers (50-32), who won the Pacific Division in 2024-25, were 36-16 against conference opponents.

Tipoff from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. The Lakers lead the all-time series 265-177, including wins in three of four games last season. Golden State is a 2.5-point favorite in the latest Warriors vs. Lakers odds from SportsLine consensus, while the over/under for total points scored is 226. 

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Before making any Warriors vs. Lakers picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven seasons. The model enters the 2025-26 NBA season on a sizzling 160-118 roll on all top-rated NBA picks, returning nearly $4,000. It is also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. Anyone following could have seen HUGE returns!

The model has simulated Warriors vs. Lakers 10,000 times and the results are in. We can tell you that the model is going Under on the point total, and it also says one side of the spread hits in nearly 60% of simulations!

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