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Buffalo Bills vs Carolina Panthers picks, predictions, odds for NFL Week 8 game

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The Buffalo Bills and Carolina Panthers play on Sunday, Oct. 26, at the Panthers’ Bank of America Stadium in a game on the NFL Week 8 schedule.

Which team will win the NFL Week 8 game?

Check out these NFL Week 8 picks and NFL Week 8 predictions for the game, which can be seen at 10 a.m. MST on FOX (stream with FUBO).

The Bills are an 8-point favorite over the Panthers in NFL Week 8 odds for the game, courtesy of BetMGM Sportsbook.

Buffalo is -425 on the moneyline, while Carolina is +325. The over/under (point total) is set at 46.5 points.

NFL Week 8 picks: Vikings at Chargers | Dolphins at Falcons | Bears at Ravens | Bills at Panthers | Jets at Bengals | 49ers at Texans | Browns at Patriots | Giants at Eagles | Buccaneers at Saints | Cowboys at Broncos | Titans at Colts | Packers at Steelers | Commanders at Chiefs | Predictions

Watch Bills at Panthers live on FUBO (free trial)

Jeremy Cluff writes: “The Bills have dropped two straight, but had an off week to get ready for this game. Josh Allen and Buffalo will get right in Carolina.”

Bookies.com: Bet the Panthers with the points vs Bills

Bill Speros writes: “The red-hot Carolina Panthers have won three straight and now own a share of the best record in the NFL against the spread (5-2). That is not a misprint. Both the Bills and Panthers last lost to the juggernaut that is the New England Patriots. The Bills come off the bye and a tough Sunday night loss to New England in Week 6. The Panthers beat the Jets Sunday. Which is like . . . beating the Jets. Josh Allen and the Bills need a win here to keep pace with the Patriots in the AFC East. That is not a misprint, either. But the Panthers’ defense keeps this one within reach for the hosts.”

The site’s formula predicts that the Bills will win the NFL Week 8 game against the Panthers.

ESPN: Bills have a 63.3% chance to beat Panthers on Sunday

The site gives the Panthers a 36.4% shot at winning the NFL Week 8 game, with the remaining percentage accounting for a tie.

Dimers: Bills 27, Panthers 20

It writes: “After extensive simulations, our model gives the Bills a win probability of 73%, while the Panthers have a win probability of 27%.”

Sportsnaut: Buffalo Bills 27, Carolina Panthers 21

Matt Johnson writes: “Styles make fights, and that’s one reason why we’re very excited by this Week 8 clash between the Buffalo Bills and the Carolina Panthers early on Sunday. What the Panthers have going for them is an offense that can run the football very efficiently (177.3 rush yards per game and 5.3 yards per carry in the last four games) versus a Bills defense that surrenders the highest yards-per-carry average (5.8) and the second-most rushing yards per game (156.3) in the NFL. Carolina’s defense (74.7 rush yards per game and 3.5 yards per carry allowed) has also been outstanding versus the run.”

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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