Leeds make four changes to the side that started their 2-0 Premier League defeat at Burnley last Saturday.
Lucas Perri starts in goal, while Jaka Bijol, Noah Okafor and Ao Tanaka come in as Karl Darlow, Pascal Struijk, Anton Stach and Jack Harrison drop to the bench.
West Ham make two changes to the team that began their 2-0 loss at home to Brentford on Monday.
Aaron Wan-Bissaka and El Hadji Malick Diouf both start, in place of Kyle Walker-Peters and Mateus Fernandes.
