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Timberwolves vs. Lakers odds, line: Proven model reveals picks for NBA matchup

The Minnesota Timberwolves take on the Los Angeles Lakers in an early-season key NBA Western Conference matchup on Friday night. Minnesota is coming off a 118-114 win at Portland on Wednesday, while Los Angeles dropped a 119-109 decision to Golden State on Tuesday. The Timberwolves (1-0), who finished sixth in the conference a year ago at 49-33, are 25-17 on the road since the start of last season. The Lakers (0-1), who were the third seed in the West at 50-32 in 2024-25, are 31-11 at home since last October. 

Tipoff from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. The Lakers lead the all-time series 87-46, but the teams split four games last season. Minnesota is a 2.5-point favorite in the latest Timberwolves vs. Lakers odds from SportsLine consensus, while the over/under for total points scored is 225.5. 

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Before making any Timberwolves vs. Lakers picks, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past seven seasons. The model enters the 2025-26 NBA season on a sizzling 160-118 roll on all top-rated NBA picks, returning nearly $4,000. It is also went 24-11 (69%) on top-rated NBA against-the-spread picks last season. Anyone following could have seen HUGE returns!

The model has simulated Timberwolves vs. Lakers 10,000 times and the results are in. We can tell you that the model is going Under on the point total, and it also says one side of the spread hits in well over 50% of simulations!

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